Hiv-neutralizing rat monoclonal antibodies against pb-1

Details Hiv-neutralizing rat monoclonal antibodies against pb-1 Hiv-neutralizing rat monoclonal antibodies against pb-1

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 39/42 (2006.01) C07K 16/10 (2006.01) C12N 5/20 (2006.01) C12N 5/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2050817

9469P/5866A 18029 TITLE OF THE INVENTION HIV-NEUTRALIZING RAT MONOCLONAL ANTIBODIES AGAINST PB-1. ABSTRACT OF THE INVENTION The preparation and characterization of rat monoclonal antibodies against a major type-specific neutralizing determinant of HIV are disclosed. The antibodies are useful in the diagnosis of AIDS and ARC, in passive immunization against exposure to HIV and in related immunotherapies against AIDS or ARC. The rat hybridomas of this invention are useful for humanization of the rat monoclonal antibodies.

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