Supernatant from mesenchymal stem cells for prevention and...

Details Supernatant from mesenchymal stem cells for prevention and... Supernatant from mesenchymal stem cells for prevention and...

A - Human Necessities

61

K

A61K 35/28 (2006.01) C12N 5/0775 (2010.01) C12N 5/0783 (2010.01) A61K 35/12 (2006.01) A61P 37/02 (2006.01)

Patent

CA 2387542

A method of reducing an immune response to a transplant in a recipient by treating said recipient with an amount of mesenchymal stem cells effective to reduce or inhibit host rejection of the transplant. The mesenchymal stem cells can be administered before, at the same time as, or after the transplant. Also disclosed is a method of inducing a reduced immune response against a host by foreign tissue, i.e., graft versus host disease, by treatment with mesenchymal stem cells.

L'invention concerne un procédé de réduction d'une réponse immunitaire à l'égard d'une greffe chez un receveur consistant à traiter le receveur avec une quantité de cellules souches mésenchymateuses efficaces pour réduire ou inhiber le rejet de la greffe. Lesdites cellules souches peuvent être administrées avant, pendant ou après la greffe. Fait aussi l'objet de cette invention un procédé d'induction d'une réponse immunitaire réduite contre un hôte par un tissu étranger, tel que la réaction de la greffe contre l'hôte et par le traitement faisant appel à des cellules souches mésenchymateuses.

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