Naphthyridine derivatives as potassium channel modulators

Details Naphthyridine derivatives as potassium channel modulators Naphthyridine derivatives as potassium channel modulators

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61P 25/08 (2006.01)

Patent

CA 2695196

This invention provided compounds of formula (I), where W and Z are, independently, CH or N, and where other substituents are defined herein. Such compounds are potassium channel modulators. The invention also provides a composition comprising a pharmaceutically acceptable carrier or excipient and at least one of the following: a pharmaceutically effective amount of a compound of formula (I); a pharmaceutically acceptable salt of a compound of formula (I); a pharmaceutically acceptable ester of a compound of formula (I). The invention also provides a method of preventing or treating a disease or disorder which is affected by activities of potassium channels, comprising administering to a patient in need thereof a therapeutically effective amount of a compound of formula (I) or a salt or ester or solvate thereof.

Cette invention propose des composés de formule (I), W et Z étant indépendamment CH ou N, et d'autres substituants étant définis ici. De tels composés sont des modulateurs des canaux potassiques. L'invention propose également une composition comportant un support ou un excipient acceptable du point de vue pharmaceutique et au moins un des éléments suivants : une quantité efficace du point de vue pharmaceutique d'un composé de formule (I) ; un sel acceptable du point de vue pharmaceutique d'un composé de formule (I) ; un ester acceptable du point de vue pharmaceutique d'un composé de formule (I). L'invention propose également un procédé de prévention ou de traitement d'une maladie ou d'un trouble sur lequel les activités des canaux potassiques ont une incidence, comportant l'administration à un patient qui en a besoin d'une quantité efficace du point de vue therapeutique d'un composé de formule (I) ou d'un sel ou ester ou solvate de celui-ci.

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