C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) C07K 1/02 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2651348
Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to the N-terminus of an immunoglobulin CH2 domain. Also disclosed are RAGE fusion protein formulations and the use of the RAGE fusion proteins and RAGE fusion protein formulations as therapeutics for RAGE-mediated pathologies.
La présente invention concerne des protéines de fusion RAGE qui comprennent des séquences polypeptidiques RAGE liées à un second polypeptide qui n'est pas un RAGE. La protéine de fusion RAGE peut utiliser un domaine du polypeptide RAGE comprenant un site de liaison du ligand RAGE et un liant inter-domaine directement lié au N-terminus d'un domaine d'immunoglobuline CH2. L'invention concerne également des formulations de protéines de fusion RAGE et l'utilisation des protéines de fusion RAGE et des formulations de protéines de fusion RAGE dans le traitement de pathologies induites par le RAGE.
Benjamin Eric J.
Mjalli Adnan M.m.
Rothlein Robert
Tian Ye Edward
Webster Jeffrey C.
Smart & Biggar
Transtech Pharma Inc.
LandOfFree
Rage fusion proteins, formulations, and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Rage fusion proteins, formulations, and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Rage fusion proteins, formulations, and methods of use thereof will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1848393