C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 215/42 (2006.01) C07C 209/84 (2006.01) C07C 213/10 (2006.01) C07C 217/60 (2006.01) C07C 217/74 (2006.01)
Patent
CA 2426158
The present invention relates to novel essentially pure venlafaxine and the process of preparation thereof. The present invention also relates to novel solvate forms of venlafaxine hydrochloride and the process of preparation thereof. Furthermore, the present invention provides a novel process for preparing venlafaxine hydrochloride from venlafaxine; the process comprises the steps of: i) preparing a mixture of venlafaxine with acetone; and ii) exposing the mixture in gaseous hydrochoric acid.
L'invention concerne une nouvelle venlafaxine sensiblement pure et le procédé permettant de la préparer. L'invention concerne également de nouvelles formes solvatées de chlorhydrate de venlafaxine et la préparation de celles-ci. L'invention concerne en outre un nouveau procédé permettant de préparer du chlorhydrate de venlafaxine à partir de venlafaxine. Ce procédé comprend les étapes suivantes : i) on prépare un mélange de venlafaxine et d'acétone; et ii) on expose ce mélange à un acide chlorhydrique gazeux.
Aronhime Judith
Dolitzky Ben-Zion
Nisnevish Gennady
Wizel Shlomit
Heenan Blaikie Llp
Teva Pharmaceutical Industries Ltd.
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