A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) C12N 15/861 (2006.01) C12N 15/864 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2384814
A rapid method for modifying a viral capsid or envelope protein with a polyethylene glycol (PEG) is described. Also provided are methods of delivering a molecule using the PEG-modified viruses of the invention. Compositions containing the PEG-modified viruses of the invention, are characterized by improved gene expression, reduced neutralizing antibody and CTL production. Also provided are viral compositions having enhanced physical stability, in which the viruses are lyophilized in a formulation having a 1:1 ratio of sucrose and mannitol are provided.
Procédé rapide servant à modifier une capside virale ou enveloppe protéinique comportant un polyéthylène glycol (PEG). Procédés servant à administrer une molécule au moyen des virus à PEG modifié. Compositions contenant ces virus à PEG modifié et caractérisées par une expression génique améliorée, un nombre limité d'anticorps neutralisants et une production de CTL. L'invention concerne également des compositions virales présentant une stabilité physique améliorée, dans lesquelles les virus sont lyophilisés dans une formulation possédant un rapport de 1:1 entre sucrose et mannitol.
Croyle Maria A.
Wilson James M.
Gowling Lafleur Henderson Llp
The Trustees Of The University Of Pennsylvania
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