Secreted alpha-helical cytokine-like protein zlmda24

C - Chemistry – Metallurgy – 12 – N

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C12N 15/24 (2006.01) C07K 14/52 (2006.01)

Patent

CA 2429044

The present invention relates to zlmda24 polynucleotide and polypeptide molecules. Zlmda24 is a novel cytokine-like polypeptide with an anti-parallel alphahelical structure. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo . Moreover, zlmda24 polynucleotides, polypeptides and antibodies can be used as a diagnostic to detect the presence of human testis tissue. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

La présente invention concerne des molécules polynucléotidiques et polypeptidiques de la protéine Zlmda24. Cette protéine Zlmda24 est un nouveau polypeptide de type cytokine présentant une structure à hélice alpha antiparallèle. Les polypeptides peuvent être utilisés dans des procédés consistant à stimuler la prolifération et/ou le développement de cellules hématopoïétiques <i>in vitro </i> et <i>in vivo</i>. de plus, les anticorps, les polypeptides et les polynucléotides de la protéine Zlmda24 peuvent être utilisés à des fins diagnostiques pour détecter la présence de tissu testiculaire humain. La présente invention concerne également des procédés permettant de produire cette protéine, des méthodes d'utilisation ainsi que des anticorps dirigés contre cette protéine.

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