Method for obtaining precursor z and use thereof for the...

Details Method for obtaining precursor z and use thereof for the... Method for obtaining precursor z and use thereof for the...

C - Chemistry, Metallurgy

12

P

C12P 9/00 (2006.01) A61P 25/00 (2006.01) C12P 15/00 (2006.01)

Patent

CA 2554461

The invention relates to a method for obtaining the molybdopterin derivative precursor Z, whereby an over-production of precursor Z occurs in host organisms by recombinant expression of precursor Z synthesizing proteins. The invention further relates to the use of precursor Z for the production of a means for the therapy of human molybdenum cofactor deficiency and associated diseases, which may be directly or indirectly attributed to an altered molybdenum cofactor synthesis, whereby precursor Z is used as essential component of said means.

L'invention concerne un procédé pour produire le précurseur Z du dérivé de molybdoptérine, caractérisé en ce qu'une expression recombinante de protéines synthétisant le précurseur Z, dans des organismes hôtes, entraîne une surproduction du précurseur Z. Cette invention concerne en outre l'utilisation de ce précurseur Z pour produire un agent servant à traiter la déficience humaine en cofacteur molybdène et des maladies associées qui sont directement ou indirectement liées à une synthèse modifiée du cofacteur molybdène, l'ingrédient principal de cet agent étant ledit précurseur Z.

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