C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/08 (2006.01) A61K 31/551 (2006.01) A61P 25/04 (2006.01)
Patent
CA 2480488
This invention relates to novel diazabicyclic biaryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro- degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
La présente invention concerne de nouveaux dérivés de biaryle diazabicyclique, qui sont des ligands cholinergiques des récepteurs nicotiniques d'acétylcholine ainsi que des modulateurs des récepteurs et des transporteurs de monoamines. Etant donné leur profil pharmacologique, les composés selon l'invention peuvent être utiles dans le traitement de maladies ou de troubles aussi divers que ceux associés au système cholinergique du système nerveux central (SNC), du système nerveux périphérique (SNP), de maladies ou de troubles associés à la contraction des muscles lisses, de maladies ou de troubles endocriniens, de maladies ou de troubles associés à la neurodégénérescence, de maladies ou de troubles associés à l'inflammation, à la douleur et de syndromes de sevrage provoqués par l'arrêt de la consommation abusive de substances chimiques.
Ahring Philip K.
Jorgensen Tino Dyhring
Nielsen Elsebet Ostergaard
Olsen Gunnar M.
Peters Dan
Mccarthy Tetrault Llp
Neurosearch A/s
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