Methods of promoting cardiac repair using growth factors...

Details Methods of promoting cardiac repair using growth factors... Methods of promoting cardiac repair using growth factors...

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 35/30 (2006.01) A61K 35/32 (2006.01) A61K 35/34 (2006.01) C12N 15/62 (2006.01) C07K 14/475 (2006.01)

Patent

CA 2670830

The present invention is directed to proteins in which a heparin binding peptide is fused to a growth factor that promotes cell growth and survival. The compound thus formed is bound to the surface of cells which are then administered to damaged tissue. The growth factor is thereby maintained at the site of administration where it promotes repair.

Cette invention concerne des protéines dans lesquelles le peptide de liaison à l'héparine est fusionné avec un facteur de croissance favorisant la croissance et la survie cellulaire. Le composé ainsi formé est lié à la surface de cellules qui sont ensuite administrées à des tissus endommagés. Ainsi, le facteur de croissance est maintenu sur le site d'administration où il favorise la réparation.

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