Viruses for the treatment of cellular proliferative disorders

Details Viruses for the treatment of cellular proliferative disorders Viruses for the treatment of cellular proliferative disorders

A - Human Necessities

61

K

A61K 35/76 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) A61M 1/14 (2006.01)

Patent

CA 2720361

Methods for treating cell proliferative disorders by administering virus to proliferative cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras- pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering an immunosuppressive agent.

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