Sustained-release composition including amorphous polymer

Details Sustained-release composition including amorphous polymer Sustained-release composition including amorphous polymer

A - Human Necessities

61

K

167/166

A61K 9/16 (2006.01) A61K 9/22 (2006.01)

Patent

CA 2324254

Provided is a sustained release composition for sustained release of a pharmaceutical substance. The composition includes a biocompatible polymer that is highly amorphous and a pharmaceutical substance in a hydrophobic ion complex with an amphiphilic material. Also provided a compressed antisolvent method for manufacturing the composition, various product forms incorporating the composition and various uses for the composition.

La présente invention concerne une composition permettant la libération prolongée d'une substance pharmaceutique. Cette composition contient un polymère biocompatible hautement amorphe dans un complexe d'ions hydrophobe associé à un matériau amphiphile. L'invention concerne également un procédé utilisant un antisolvant comprimé pour fabriquer la composition, différentes formes de produit incorporant la composition, et diverses utilisations convenant à la composition.

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