C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/04 (2006.01) G01N 33/536 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2501131
Genes that are differentially expressed in subtypes of renal cell carcinomas are disclosed as are their polypeptide products. This information is utilized to produce nucleic acid and antibody probes and sets of such probes that are specific for these genes and their products. Methods employing these probes, including hybridization and immunological methods, are used to determine the subtype of a renal cell tumor sample from a subject based on the differential expression of such genes that is characteristic of the cancer subtype.
La présente invention concerne des gènes exprimés de manière différentielle dans des sous types de carcinomes de cellules rénales ainsi que leur produits polypeptidiques. On utilise ces informations pour produire des acides nucléiques et des sondes anticorps et des ensembles de ces sondes spécifiques de ces gènes et de leurs produits. On utilise des techniques mettant en oeuvre ces sondes, y compris des techniques immunologiques et d'hybridation, pour déterminer le sous type d'un prélèvement de tumeur de cellules rénales d'un patient fondées sur l'expression différentielle de ces gènes qui est caractéristique de ce sous type de cancer.
Takahashi Masayuki
Teh Bin Tean
Smart & Biggar
Takahashi Masayuki
Teh Bin Tean
Van Andel Research Institute
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