C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 38/16 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C12N 15/12 (2006.01) G01N 33/563 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2087095
2087095 9201787 PCTABS00010 This invention concerns binding domains e.g. single chain variable domains which are synthetic analogues of other single chain variable domains of members of an immunoglobulin family or superfamily. In the analogue, one or more amino acid residues is altered as compared to the other domain, so that the analogue is more hydrophilic than the natural domain. The altered amino acid is substituted with a residue which occurs in an analogous position in a member of an immunoglobulin family or superfamily. This increased hydrophilicity means that the synthetic analogue will show less non-specific binding than the natural domain. The analogue may retain the binding specificity of the natural domain. Alternatively, the complementarity determining regions may be altered to change the binding specificity. The invention also concerns methods for making these binding domains.
Chiswell David J.
Jackson Ronald H.
Johnson Kevin S.
Bereskin & Parr
Cambridge Antibody Technology Limited
Chiswell David J.
Jackson Ronald H.
Johnson Kevin S.
LandOfFree
Binding domains does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Binding domains, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Binding domains will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1850406