C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) C07H 21/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/44 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2170641
An expression vector cDNA library derived from senescent cells has been used to isolate cDNA clones that encode inhibitors of DNA synthesis. Such inhibitors play a role in cellular senescence, aging and neoplasia. Antisense nucleic acids reduce the inhibition of DNA synthesis. The invention concerns such molecules, their inhibitors, antagonists and derivatives. The invention also concerns diagnostic, therapeutic and in vitro uses for all such agents.
Une banque d'ADNc de vecteur d'expression dérivée de cellules sénescentes a été utilisée pour isoler des clones d'ADNc codant des inhibiteurs de la synthèse d'ADN. De tels inhibiteurs jouent un rôle dans la sénescence, le vieillissement et la néoplasie cellulaires. Des acides nucléiques antisens réduisent l'inhibition de la synthèse d'ADN. L'invention se rapporte à de telles molécules ainsi qu'à leurs inhibiteurs, antagonistes et dérivés. L'invention se rapporte également aux utilisations diagnostiques, thérapeutiques et in vitro de tous ces agents.
Baylor College Of Medicine
Fetherstonhaugh & Co.
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