Hpma - docetaxel or gemcitabine conjugates and uses therefore

Details Hpma - docetaxel or gemcitabine conjugates and uses therefore Hpma - docetaxel or gemcitabine conjugates and uses therefore

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2739757

Disclosed are water-soluble compositions of gemcitabine and docetaxel formed by conjugating the gemcitabine or docetaxel to a water-soluble polymer such as N-2-hydroxypropyl methacrylamide (HPMA). Also disclosed are methods of using the compositions of the invention for the treatment of cancer.

La présente invention concerne des compositions solubles dans leau de gemcitabine et de docétaxel formées par conjugaison de gemcitabine ou de docétaxel à un polymère soluble dans leau tel que le N-2-hydroxypropyl méthacrylamide (HPMA). La présente invention concerne également des procédés dutilisation des compositions de linvention destinées au traitement du cancer.

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