Ligands specific for an isoform of the prion protein

Details Ligands specific for an isoform of the prion protein Ligands specific for an isoform of the prion protein

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61P 25/28 (2006.01) C07H 21/02 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2410028

Prion protein, PrP, ligands are provided, especially protease resistant and nuclease resistant ligands. Ligands selective for isoforms such as PrPSC can be prepared. In a related aspect, the PrP ligands are used in diagnostic tests for PrP. The ligands also have potential for a role in the development of therapeutic methods for treatment of TSEs.

L'invention concerne une protéine prion, un PrP, des ligands, notamment des ligands résistant aux protéases et aux nucléases. Selon cette invention, des ligands sélectifs destinés aux isoformes, tels que PrP?SC¿, peuvent être préparés. Dans un autre aspect de l'invention, les ligands PrP sont utilisés dans des essais diagnostiques destinés à un PrP. Les ligands sont également efficaces dans le développement de procédés thérapeutiques destinés au traitement d'encéphalopathies spongiformes transmissibles (TSE).

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