Process for the preparation of substituted...

Details Process for the preparation of substituted... Process for the preparation of substituted...

C - Chemistry, Metallurgy

07

D

C07D 487/06 (2006.01) A61K 31/5517 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01) C07D 209/00 (2006.01) C07D 243/00 (2006.01) C07D 471/00 (2006.01) C07D 487/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2376707

The invention concerns a method for preparing enantiopure diazepino-indolone of formula (I) which consists in the intramolecular cyclisation of a product of formula (II) wherein A, B, X1, X2, Z, Z1, Z2 and R are as defined in the description, in the presence of a weak Lewis acid catalyst.

Méthode de préparation de diazépino-indolone énantiomériquement pure de formule (I) qui comprend la cyclisation intramoléculaire d'un produit de formule (II) où A, B, X?1¿, X?2¿, Z, Z?1¿, Z?2¿, et R sont tels que définis dans la description, en présence d'un catalyseur acide de Lewis faible.

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