Use of 2-pyridylcarboxaldehyde isonicotinoyl hydrazone...

Details Use of 2-pyridylcarboxaldehyde isonicotinoyl hydrazone... Use of 2-pyridylcarboxaldehyde isonicotinoyl hydrazone...

A - Human Necessities

61

K

A61K 31/4402 (2006.01) A61K 31/4436 (2006.01) A61K 31/444 (2006.01) A61P 7/00 (2006.01) A61P 39/04 (2006.01)

Patent

CA 2383721

The present invention provides 2-pyridylcarboxaldehyde isonicotinoyl hydrazone (PCIH) analogues suitable for use as in vivo iron chelators, the PCIH analogue having Formula (1) wherein R1 is an aromatic or heterocyclic group and R2 is either H or OH; isomers thereof or salts thereof; pharmaceutical compositions containing the analogues; and uses of the analogues in the treatment of iron- overload diseases.

La présente invention concerne des analogues de 2-pyridylcarboxaldehyde isonicotinoyl hydrazone (PCIH) qui peuvent être utilisés comme agents chélatants du fer in vivo , l'analogue de PCIH étant représenté par la formule (1) dans laquelle R1 représente un groupe aromatique ou hétérocyclique et R2 représente un atome d'hydrogène ou bien un groupe hydroxyle. Elle concerne aussi des isomères ou des sels de ces analogues, de compositions pharmaceutiques contenant ces analogues ainsi que leurs utilisations dans le traitement des maladies dues à des surcharges de fer.

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