Novel lna compositions and uses thereof

Details Novel lna compositions and uses thereof Novel lna compositions and uses thereof

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C07H 19/04 (2006.01)

Patent

CA 2459347

Modified LNA units are provided that comprises unique base groups. Desirable nucleobase and nucleosidic base substitutions can mediate universal hybridization when incorporated into nucleic acid strands. The novel LNA compounds may be used in a wide variety of applications, such as PCR primers, sequencing, synthesis of antisense oligonucleotides, diagnostics and the like.

Cette invention concerne des unités modifiées d'acides nucléiques verrouillés (LNA) qui comprennent des groupes de bases uniques. Des substitutions appropriées de nucléobases et de bases nucléosidiques peuvent induire une hybridation universelle lorsqu'elles sont intégrées à des brins d'acides nucléique. Les nouveaux composés d'acides nucléiques verrouillés (LNA) peuvent s'utiliser dans les applications les plus diverses, notamment : amorces pour réaction en chaîne de la polymérase, séquençage, synthèse d'oligonucléotides antisens, diagnostics.

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