Cycloalkane derivatives

Details Cycloalkane derivatives Cycloalkane derivatives

C - Chemistry, Metallurgy

07

C

167/179, 260/558

C07C 43/20 (2006.01) A61K 31/085 (2006.01) C07C 17/14 (2006.01) C07C 17/361 (2006.01) C07C 43/21 (2006.01) C07C 43/225 (2006.01) C07C 43/23 (2006.01) C07C 45/59 (2006.01) C07C 49/753 (2006.01) C07C 255/16 (2006.01) C07C 255/37 (2006.01)

Patent

CA 2006096

A B S T R A C T TITLE: CYCLOALKANE DERIVATIVES The invention concerns a cycloalkane derivative of the formula I, Image I wherein Ar1 is optionally substituted phenyl or naphthyl; A1 is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo- (3-6C)alkylene; Ar2 is optionally substituted phenylene, or a 6 membered heterocyclene moiety containing up to three nitrogen atoms; R1 is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)3alkynyl, cyano-(1- 4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; and R2 and R3 together form a (3-6C)alkylene group which defines an optionally substituted ring having 4 to 7 ring atoms; or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.

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