Mutants of streptococcal toxin c and methods of use

Details Mutants of streptococcal toxin c and methods of use Mutants of streptococcal toxin c and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/09 (2006.01) C07K 14/315 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2273824

This invention is directed to mutant SPE-C toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-C toxin has at least one amino acid change and is substantially non-lethal compared with the wild type SPE-C toxin. The mutant SPE-C toxins can form vaccine compositions useful to protect animals against the biological activities of wild type SPE-C toxin.

Cette invention, qui a trait à des toxines streptococciques C (SPE-C) mutantes ou à des fractions de celles-ci, porte également sur des vaccins et des compositions à usage pharmaceutique ainsi que sur des méthodes d'utilisation desdits vaccins et compositions. La toxine SPE-C préférée de l'invention, qui possède au moins une modification aminoacide, n'a pas d'incidence léthale, à l'inverse de la toxine SPE-C de type sauvage. Ces toxines mutantes peuvent entrer dans des compositions vaccinales efficaces en matière de protection contre les activités à caractère biologique de la toxine SPE-C de type sauvage chez l'animal.

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