Antisense oligonucleotide inhibition of the ras gene

Details Antisense oligonucleotide inhibition of the ras gene Antisense oligonucleotide inhibition of the ras gene

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C07K 14/82 (2006.01) C12N 9/02 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2111472

2111472 9222651 PCTABS00018 Compositions and methods are provided for the modulation of expression of the human ras gene in both the normal and activated forms. Oligonucleotides are provided which are specifically hybridizable with RNA or DNA deriving from the human ras gene, having nucleotide units sufficient in identity and number to effect such specific hybridization. Oligonucleotides or oligonucleotide analogs specifically hybridizable with a translation initiation site or with the codon-12 mutation of activated ras are provided. Such oligonucleotides and oligonucleotide analogs can be used for diagnostics as well as for research purposes. Methods are also disclosed for modulating ras gene expression in cells and tissues using the oligonucleotides or oligonucleotide analogs provided, and for specific modulation of expression of the activated ras gene. Methods for diagnosis, detection and treatment of conditions arising from the activation of the H-ras gene are also disclosed.

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