A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/06 (2006.01) A61K 38/12 (2006.01) A61K 38/13 (2006.01) C12Q 1/26 (2006.01)
Patent
CA 2177175
A method for increasing bioavailability of an orally administered hydrophobic pharmaceutical compound, which comprises orally administering the pharmaceutical compound to a mammal in need of treatment with the compound concurrently with a bioenhancer comprising an inhibitor of a cytochrome P450 3A enzyme or an inhibitor of P-glycoprotein-mediated membrane transport, the bioenhancer being present in sufficient amount to provide bioavailability of the compound in the presence of the bioenhancer greater than the bioavailability of the compound in the absence of the bioenhancer.
Procédé permettant d'accroître la biodisponibilité d'un composé pharmaceutique hydrophobe administré par voie orale, qui consiste à administrer conjointement par voie orale le composé pharmaceutique à un mammifère nécessitant un traitement par ce composé et un biostimulant contenant un inhibiteur d'enzyme P450 3A ou un inhibiteur de transport membranaire par P-glycoprotéine, le biostimulant étant présent en quantité suffisante pour conférer une biodisponibilité au composé supérieure à la biodisponibilité que présenterait le composé en l'absence de ce biostimulant.
Benet Leslie
Wu Chi Yuan
Smart & Biggar
The Regents Of The University Of California
LandOfFree
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