Treating or preventing cancers over-expressing reg4 or kiaa0101

Details Treating or preventing cancers over-expressing reg4 or kiaa0101 Treating or preventing cancers over-expressing reg4 or kiaa0101

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/475 (2006.01) C07K 16/32 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2660516

The invention features a method for inhibiting growth of a cancer cell by contacting the cell with a composition of an siRNA that inhibits expression of REG4 or KIAA0101. Methods of treating cancer are also within the invention. The invention also features products, including nucleic acid sequences and vectors as well as to compositions comprising them, useful in the provided methods. The invention also provides a method for inhibiting of tumor cell, for example pancreatic cancer cell, prostatic cancer cell, breast cancer cell, and bladder cancer cell, particularly pancreatic ductal adenocarcinoma (PDAC) by inhibiting REG4 gene. The present invention also relates to methods of treating or preventing PDAC in a subject comprising the step of administering to said subject a pharmaceutically effective amount of an antibody or fragment thereof that binds to a protein encoded by REG4. The present invention also relates to methods of diagnosing chemo-radiation therapeutic resistance of a cancer. The present invention also provides therapeutic agents or methods for treating cancer using the polypeptides. The polypeptides of the present invention are composed of an amino acid sequence which comprises polypeptide which comprises QKGIGEFF/SEQ ID NO: 21. The polypeptides of the present invention can be introduced into cancer cells by modifying the polypeptides with transfection agents such as poly-arginine.

L'invention porte: sur une méthode d'inhibition de la croissance de cellules cancéreuses en les mettant en contact avec une préparation faite d'un ARNsi inhibant l'expression du REG4 ou du KIAA0101; sur des méthodes de traitement du cancer; sur des produits dont des séquences et vecteurs d'acides nucléiques; sur des préparations les comprenant et utilisées dans les susdites méthodes de traitement; sur une méthode d'inhibition de cellules cancéreuses du pancréas, de la prostate, du sein, de la vessie, et en particulier de l'adénocarcinome ductal du pancréas (PDAC) par inhibition du gène REG4; sur des méthodes de traitement ou prévention du PDAC consistant à administrer à un sujet une dose à efficacité pharmaceutique d'un anticorps ou de ses fragments se fixant à une protéine codée par le REG4; sur des méthodes de diagnostic de la résistance d'un cancer à une radio-chimiothérapie; sur des agents et méthodes thérapeutiques de traitement du cancer utilisant des polypeptides de l'invention comprenant: une séquence d'acides aminés comprenant un polypeptide comprenant la séquence QKGIGEFF/SEQ ID NO: 21, lesdits polypeptides pouvant être introduits dans des cellules cancéreuses en les modifiant avec des agents de transfection tels que la poly-arginine.

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