Prevention and treatment of ischemic events and reperfusion...

Details Prevention and treatment of ischemic events and reperfusion... Prevention and treatment of ischemic events and reperfusion...

A - Human Necessities

61

K

A61K 38/49 (2006.01) A61K 38/48 (2006.01)

Patent

CA 2127199

A treatment of ischemia and the attendant reperfusion injury entails the administration plasmin and plasmin-forming proteins, including lys-plasminogen and similar substances. Lys-plasminogen, which can be obtained from the proteolytic cleavage of glu-plasminogen, has been found to have a protective effect on tissue that has been injured by ischemic conditions. the administration of lys-plasminogen can used to treat subjects during the time of reperfusion and after reperfusion has already occurred. Lys-plasminogen also can be administered in conjunction with clot lysis therapies, such as those that employ tissue plasminogen activator and the like.

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