C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61P 25/02 (2006.01)
Patent
CA 2635445
The present invention relates to novel therapeutic or prophylactic treatment in human subjects. The present invention results in part from the discovery that antagonists of IL-18R.alpha. are effective in vivo for treating diseases. Accordingly, the invention provides a method of treating, preventing or ameliorating the symptoms of an autoimmune or demyelinating disease (such as multiple sclerosis) in a subject, preferably a human subject, said method comprising administering to the subject a therapeutically effective amount of an antagonist of IL-18R.alpha.. The invention also pertains to the use of an antagonist of IL-18R.alpha. in the manufacture of a medicament for the treatment of an autoimmune or demyelinating diseases (such as multiple sclerosis).
La présente invention concerne un nouveau traitement thérapeutique ou prophylactique de sujets humains. Elle résulte en partie de la découverte que des antagonistes de l'IL-18R.alpha. sont efficaces in vivo pour traiter des maladies. En conséquence, l'invention concerne un procédé de traitement, de prévention ou d'amélioration des symptômes d'une maladie auto-immune ou démyélinisante (par exemple la sclérose en plaques) chez un sujet, de préférence un sujet humain, ledit procédé comprenant l'administration au sujet d'une quantité thérapeutiquement efficace d'un antagoniste de l'IL-18R.alpha.. L'invention concerne également l'utilisation d'un antagoniste de l'IL-18R.alpha. pour préparer un médicament destiné à traiter des maladies auto-immunes ou démyélinisantes (par exemple la sclérose en plaques).
Kirby Eades Gale Baker
University Of Zurich
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