Methods of therapy and diagnosis using targeting of cells...

Details Methods of therapy and diagnosis using targeting of cells... Methods of therapy and diagnosis using targeting of cells...

C - Chemistry, Metallurgy

07

H

C07H 21/02 (2006.01)

Patent

CA 2522421

Certain cells, including types of cancer cells such as KIRHy1, are capable of expressing KIRHy1 mRNA. Targeting using KIRHy1 polypeptides, nucleic acids encoding for KIRHy1 polypeptides and anti-KIRHy1 antibodies provides a method of killing or inhibiting that growth of cancer cells that express the KIRHy1 protein. Methods of therapy and diagnosis of disorders associated with KIRHy1 protein-expressing cells, such as acute myelogenous leukemia (AML), are described.

Sachant que certaines cellules, y compris des types de cellules cancéreuses comme KIRHy1 sont capables d'exprimer de l'ARNm de KIRHy1, le ciblage reposant sur des polypeptides KIRHy1, des acides nucléiques qui codent ces polypeptides et des anticorps anti-KIRHy1 constitue un procédé de destruction ou d'inhibition de la croissance cancéreuse qui exprime la protéine KIRHy1. L'invention concerne également des procédés de thérapie et de diagnostic des troubles associés aux cellules exprimant ladite protéine KIRHy1, comme les cellules de la leucémie myélogène aiguë.

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