Non-invasive enzyme screen for tissue remodelling-associated...

Details Non-invasive enzyme screen for tissue remodelling-associated... Non-invasive enzyme screen for tissue remodelling-associated...

G - Physics

01

N

G01N 33/574 (2006.01) C12Q 1/37 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2425761

methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzyme complexes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of metastatic cancer by the identification of high molecular weight enzyme complexes comprising MMPs.

L'invention concerne des méthodes et des kits permettant de diagnostiquer la présence et de pronostiquer l'apparition d'états associés au remodelage d'un tissu, qui impliquent le présence de complexes enzymatiques dans un échantillon biologique. Ces méthodes consistent, en particulier, à diagnostiquer la présence ou à pronostiquer l'apparition d'un cancer métastatique par identification de complexes enzymatiques de poids moléculaire élevé comprenant des métalloprotéinases matricielles.

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