Improved detection of gene expression

Details Improved detection of gene expression Improved detection of gene expression

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2755734

An oligonucleotide, primer or probe comprises the nucleotide sequence of any of SEQ ID NO. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 1 1, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 44, 61, 62 or 63. The oligonucleotide, primer or probe is useful for the detection of the methylation status of a gene. The oligonu-cleotides find application in the diagnosis and treatment of cancer.

L'invention concerne un oligonucléotide, une amorce ou une sonde comprenant la séquence nucléotidique de l'une quelconque parmi SEQ ID NO. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 44, 61, 62 ou 63. L'oligonucléotide, l'amorce ou la sonde est utile pour la détection du statut de méthylation d'un gène. Les oligonucléotides trouvent des applications dans le diagnostic et le traitement du cancer.

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