Method for producing a nucleic-acid-containing complex...

A - Human Necessities – 61 – K

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Details

A61K 31/7088 (2006.01) A61K 31/7105 (2006.01) A61K 31/711 (2006.01) A61K 31/713 (2006.01) A61K 47/16 (2006.01) A61K 47/24 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2609032

It is intended to provide a method for producing a nucleic acid-containing complex preparation which can be subjected to filter sterilization and administered intravenously to human and in which the stability of a polynucleotide contained in the nucleic acid-containing complex preparation is maintained. The invention relates to the method for producing a nucleic acid- containing complex preparation characterized by mixing a solution in which two polynucleotides which can form a double strand (for example polyI and polyC) in a single stranded form are contained in the same solution and a cationic carrier or a raw material solution before forming a cationic carrier and subjecting the mixture to a dispersion treatment.

L'invention a pour objet un procédé servant à produire une préparation complexe contenant des acides nucléiques laquelle peut être soumise à une stérilisation sur filtre et administrée de façon intraveineuse à des êtres humains et dans laquelle la stabilité d'un polynucléotide contenu dans la préparation complexe contenant des acides nucléiques est maintenue. L'invention concerne un procédé servant à produire une préparation complexe contenant des acides nucléiques caractérisé en ce qu'on mélange une solution dans laquelle deux polynucléotides qui peuvent former un double brin (par exemple polyl et polyC) sous une forme de simple brin sont contenus dans la même solution et un véhicule cationique ou une solution de matière brute servant à former un véhicule cationique et en ce qu~on soumet le mélange à un traitement de dispersion.

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