C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/00 (2006.01) C07K 1/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 9/00 (2006.01) C12N 9/64 (2006.01) C12Q 1/68 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2392751
The present invention relates to novel prostate gland related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "prostate gland antigens", and the use of such prostate gland antigens for detecting disorders of the prostate gland, particularly the presence of prostate cancer and prostate cancer metastases. More specifically, isolated prostate gland associated nucleic acid molecules are provided encoding novel prostate gland associated polypeptides. Novel prostate gland polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human prostate gland associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the prostate, including prostate cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
La présente invention concerne des polynucléotides associés à la glande prostatique et des polypeptides codant pour ces polynucléotides, appelés collectivement ici <= antigènes de la glande prostatique >=, ainsi que l'utilisation desdits antigènes pour la détection d'affections de la prostate, en particulier du cancer de la prostate, métastasé ou non. Plus précisément, l'invention concerne des molécules d'acide nucléique isolées associées à la glande prostatique qui codent pour les nouveaux polypeptides associés à la glande prostatique, ainsi que des polypeptides et anticorps de la glande prostatique que se lient à ces polypeptides. L'invention concerne également des vecteurs, des cellules hôtes et des méthodes synthétiques et recombinantes permettant de produire des polynucléotides et/ou des polypeptides associés à la glande prostatique humaine. Par ailleurs, l'invention concerne des méthodes diagnostiques et thérapeutiques utiles pour le diagnostic, le traitement, la prévention e/ou le pronostic de troubles de la prostate, dont le cancer, ainsi que des méthodes de traitement de tels troubles. Sont également décrites des méthodes de criblage permettant d'identifier des agonistes des polynucléotides et polypeptides de l'invention, ainsi que des méthodes et/ou des compositions propres à inhiber la production et la fonction des polypeptides selon l'invention.
Barash Steven C.
Rosen Craig A.
Ruben Steven M.
Barash Steven C.
Human Genome Sciences Inc.
Mbm & Co.
Rosen Craig A.
Ruben Steven M.
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