Lhrh antagonist peptides

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 7/23 (2006.01) A61K 38/08 (2006.01) A61K 38/09 (2006.01) A61P 5/00 (2006.01) A61P 35/00 (2006.01) C07K 7/08 (2006.01)

Patent

CA 2219460

Novel LHRH antagonist peptides, pharmaceutical compositions thereof, and methods of use thereof, are disclosed. The LHRH antagonist comprise a peptide compound, wherein a residue of the peptide compound corresponding to the amino acid at position 6 of natural mammalian LHRH comprises a hydrophilic N-acyl moiety, a dipolar moiety, a sulfonium moiety, a receptor-modifying moiety or a small polar moiety.

L'invention décrit des peptides antagonistes de la LH-RH d'un type nouveau, des compositions pharmaceutiques à base de ces derniers et des procédés pour les utiliser. Lesdits antagonistes de la LH-RH contiennent un composé peptidique, un reste dudit composé correspondant à l'acide aminé en position 6 de la LH-RH mammalienne naturelle comportant une fraction hydrophile N-acyle, une fraction dipolaire, une fraction sulfonium, une fraction modificatrice de récepteur ou une petite fraction polaire.

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