Compositions and methods for treating pathologic...

A - Human Necessities – 61 – K

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A61K 38/16 (2006.01) A61K 31/4196 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 19/02 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2693001

Compounds, compositions and methods for inhibiting vascular permeability and pathologic angiogenesis by modulating a signaling pathway delineated herein are described. Moreover, methods for producing and screening compounds and compositions capable of modulating the signaling pathway described herein, inhibiting vascular permeability, and inhibiting pathologic angiogenesis are also provided.

Linvention concerne des composés, des compositions et des méthodes qui inhibent la perméabilité vasculaire et l'angiogenèse pathologique en y modulant une voie de signalisation. L'invention concerne en outre des méthodes de production et de criblage de composés et de compositions pouvant moduler ladite voie de signalisation et inhiber la perméabilité vasculaire et l'angiogenèse pathologique.

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