Transdermal acrylic multipolymer drug delivery system

A - Human Necessities – 61 – L

Patent

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Details

A61L 15/58 (2006.01) A61F 13/02 (2006.01) A61K 9/70 (2006.01) A61L 15/18 (2006.01) A61L 15/44 (2006.01)

Patent

CA 2044132

A dermal composition comprising a drug, a multipolymer of ethylene-vinyl acetate, a acrylic polymer, and optionally one or more mo???mers, a natural or synthetic rubber and a tackifying agent. The ratio of the multipolymer to the rubber is, respectively, about 1:1 to about 10:1 and more preferably, 1:1 to 5:1 and more preferably 3:1. The dermal composition can optionally contain a crosslinking agent, tackifiers, penetration enhancers and other ingredients known for use in adhesives for the transdermal delivery of drugs. The dermal compositions can be produced by a variety of methods known in the preparation of drug containing adhesive preparations including the homogenous mixing of the multipolymer, drug and optional crosslinking agent and additional ingredients in solution or suspension or emulsion followed by removal of excess solvent.

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