Method for purifying the rabies virus

Details Method for purifying the rabies virus Method for purifying the rabies virus

A - Human Necessities

61

K

A61K 39/205 (2006.01) A61P 31/14 (2006.01) A61P 37/04 (2006.01) C12N 7/01 (2006.01) C12N 7/02 (2006.01)

Patent

CA 2757895

The subject matter of the invention is a method for purifying the rabies virus, comprising a single step of ion exchange chromatography, said step being a cation exchange chromatography according to which: a) the supernatant of a culture of cells infected with this virus is brought into contact with a cation exchange chromatography substrate comprising a matrix of polymethacrylate onto which sulphoisobutyl groups have been grafted such that the rabies virus binds to this substrate, and b) the virus is eluted from the substrate thereof.

L'invention a pour objet un procédé de purification du virus rabique comprenant une seule étape de chromatographie par échange d'ions, la dite étape étant une chromatographie par échange de cations selon laquelle : a) on met en contact le surnageant d'une culture de cellules infectées par ce virus avec un support de chromatographie échangeur de cations comprenant une matrice de polyméthacrylate sur laquelle ont été greffés des groupements sulfoisobutyl de telle sorte que le virus rabique se fixe sur ce support, et b) on élue le virus de son support.

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