Promiscuous her-2/neu cd4 t cell epitopes

Details Promiscuous her-2/neu cd4 t cell epitopes Promiscuous her-2/neu cd4 t cell epitopes

C - Chemistry, Metallurgy

07

K

C07K 14/82 (2006.01) A61K 35/14 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) A61P 37/04 (2006.01) C07K 7/08 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/62 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2660178

The present invention relates to the discovery of novel T cell epitopes of the human HER-2/Neu protein that is promiscuous for at least 25 different HLA-DR alleles. The invention also relates to compositions that contain one of the novel epitopes or a fusion peptide of such a epitope and a heterologous polypeptide. Further disclosed herein is the use of the epitopes or their fusion peptides, and compositions containing the epitopes or their fusion peptides.

La présente invention concerne la découverte de nouveaux épitopes de cellule T de la protéine HER-2/Neu humaine mêlée à au moins 25 allèles HLA-DR différents. L'invention concerne également des compositions qui contiennent un des nouveaux épitopes ou un peptide de fusion d'un tel épitope et d'un polypeptide hétérologue. Sont en outre décrites ici l'utilisation des épitopes ou de leurs peptides de fusion ainsi que des compositions contenant les épitopes ou leurs peptides de fusion.

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