Viral mutants that selectively replicate in targeted human...

Details Viral mutants that selectively replicate in targeted human... Viral mutants that selectively replicate in targeted human...

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A01N 63/00 (2006.01) A61K 31/711 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) C07K 14/075 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2449013

Oncolytic viruses are described that have favorable anti-cancer activity and that are produced by random mutagenesis and subsequent bio-selection on cancer cells wherein the viruses are preferably adenoviruses having at least one mutation in the i-leader sequence of the viral major late transcriptional unit.

L'invention se rapporte à des virus oncolytiques qui présentent une activité anticancéreuse positive et qui sont produits par mutagenèse aléatoire et par bio-sélection ultérieure sur des cellules cancéreuses, ces virus étant de préférence des adénovirus présentant au moins une mutation dans la séquence de tête i de la dernière et principale unité de transcription virale.

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