Anti-inflammatory bioactive glass particulates

Details Anti-inflammatory bioactive glass particulates Anti-inflammatory bioactive glass particulates

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/72 (2006.01) A61K 33/00 (2006.01) A61K 45/06 (2006.01) A61P 29/00 (2006.01) A61P 41/00 (2006.01)

Patent

CA 2372384

Compositions and methods for systemically minimizing the inflammatory effects of TNF-.alpha. are disclosed. The compositions include particles of bioactive glass with a particle size less than about 20 µm, alone or in combination with anti-inflammatory agents and other therapeutic agents. The compositions can include an appropriate carrier for oral, intramuscular, intraperitoneal or intravenous administration. When administered to a patient, the particles bring about elevated levels of IL-6 and do not cause elevated levels of TNF-.alpha..

L'invention porte sur des compositions et procédés réduisant systémiquement les effets inflammatoires du TNF alpha . Lesdites compositions comportent du verre bioactif en particules de moins de 20 mu m, seules ou combinées à des agents anti-inflammatoires ou d'autres agents thérapeutiques. Elles peuvent également comporter un excipient se prêtant à l'administration par voie orale, intramusculaire, intrapéritonéale ou intraveineuse. Lorsqu'administrées à un patient, lesdites particules provoquent des niveaux élevés d'IL-6 sans élever ceux de TNF alpha .

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