Peptides having thymopoietin-like activity

Details Peptides having thymopoietin-like activity Peptides having thymopoietin-like activity

C - Chemistry, Metallurgy

07

K

530/7.48

C07K 14/66 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1157466

ORTH 364 ABSTRACT PEPTIDES HAVING THYMOPOIETIN-LIKE ACTIVITY There are disclosed peptides having the following formula: wherein A is Image or Image ; X is a suitable neutral, aliphatic or aromatic amino acid residue; e.g., one selected from the group consisting of Image and SAR; Z is Image ; Image Y is Image or SAR; B is Image or Image ; m is 3 or 4; n is 1, 2, or 3; R"' is hydrogen, C1-C7 alkyl, C6-C12 aryl, or C1-C7 alkanoyl; and R and R' are substituents which do not substantially affect the biological activity of the peptides, provided that Image is excluded. These peptides have the capability of inducing the differentiation of T-lymphocytes but not of complement receptor (CR+) B-lymphocytes and thus are useful in a number of therapeutic areas. Also provided are derivatives of the peptides, therapeutic compositions, and methods for use of the compositions.

348982

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