Alkaline phosphatase enzymes having improved specific...

Details Alkaline phosphatase enzymes having improved specific... Alkaline phosphatase enzymes having improved specific...

C - Chemistry, Metallurgy

12

N

195/39, 195/1.22

C12N 15/52 (2006.01) C12N 5/10 (2006.01) C12N 9/00 (2006.01) C12N 9/16 (2006.01) G01N 33/535 (2006.01)

Patent

CA 2035826

ABSTRACT The present invention involves the construction of several mutations in the Escherichia coli alkaline phosphatase gene, that result in the production of an enzyme having an improved specific activity. The resultant mutant enzymes have up to 1.5- to 36-fold higher specific activity, while retaining a temperature stability that is significantly higher than that of mammalian alkaline phosphatase enzymes. The utility of mutant E. coli alkaline phosphatase as an enzyme label in binding assays is also demonstrated. 47

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