C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/16 (2006.01) A61K 31/47 (2006.01) A61K 31/5377 (2006.01) C07D 413/04 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2589629
The present invention is directed to certain quinoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
La présente invention concerne des dérivés de quinoline pouvant être employés en tant qu'antagonistes de récepteurs de neurokinine-1 (NK-1), et en tant qu'inhibiteurs de la tachykinine et en particulier de la substance P. La présente invention concerne également les formules pharmaceutiques comprenant ces composés au titre de principes actifs, ainsi que l'emploi desdits composés et de leurs formules dans le traitement de certains troubles, dont les vomissements, l'incontinence urinaire, la dépression et l'anxiété.
Devita Robert J.
Jiang Jinlong
Mills Sander G.
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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