Methods for bone treatment by modulating an arachidonic acid...

Details Methods for bone treatment by modulating an arachidonic acid... Methods for bone treatment by modulating an arachidonic acid...

A - Human Necessities

61

K

A61K 31/7088 (2006.01) A61K 31/05 (2006.01) A61K 31/122 (2006.01) A61P 19/00 (2006.01)

Patent

CA 2619608

Methods for promoting osteogenesis to accelerate or enhance bone fracture healing, treat bone defects, and enhance bone formation are disclosed. The methods modulate an arachidonic acid metabolic or signaling pathway in general, and, in particular, utilize 5- lipoxygenase inhibitors. These molecules can be delivered alone or in combination with one or more agents that inhibit bone resorption, regulate calcium resorption from bone, enhance bone accumulation, enhance bone formation, induce bone formation, impair growth of microorganisms, reduce inflammation, and/or reduce pain.

L'invention concerne des méthodes d'activation de l'ostéogénèse destinées à: accélérer ou améliorer la guérison d'une fracture osseuse; traiter des déformations osseuses; et améliorer la formation osseuse. Les méthodes de l'invention permettent de moduler une voie métabolique ou de signalisation de l'acide arachidonique, en général, et d'utiliser des inhibiteurs de la 5-lipoxygénase, en particulier. Ces molécules peuvent être administrées seules ou en association avec un ou plusieurs agents qui inhibent la résorption osseuse, régulent la mobilisation osseuse du calcium, améliorent l'accumulation osseuse, améliorent ou induisent la formation osseuse, compromettent la croissance de micro-organismes, réduisent l'inflammation et/ou la douleur.

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