Polynucleotide reagents having nonnucleotidic moieties, and...

Details Polynucleotide reagents having nonnucleotidic moieties, and... Polynucleotide reagents having nonnucleotidic moieties, and...

C - Chemistry, Metallurgy

07

H

C07H 15/18 (2006.01) C07F 9/655 (2006.01) C07H 15/04 (2006.01) C07H 21/00 (2006.01) C07H 23/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2196806

Methods and reagents are provided for synthesizing polynucleotides containing modified deoxyribose residues. Monomeric reagents having structural formula (I), wherein R1, R2, R3, R4 and R5 are as defined herein, are used to create polynucleotides having nonnucleotidic moieties -A-Z-(R9)n at the 1 position of selected deoxyribose units. The polynucleotides so provided are useful in a variety of hybridization assay formats.

Des procédés et des réactifs sont destinés à la synthèse de polynucléotides contenant des restes de désoxyribose modifiés. Les réactifs monomères ayant la formule développée (I), dans laquelle R?1¿, R?2¿, R?3¿, R?4¿ et R?5¿ sont tels que définis dans la description, sont utilisés pour créer des polynucléotides présentant des fractions non nucléotidiques -A-Z-(R?9¿)¿n? à la position 1 des unités de désoxyribose sélectionnées. Ces polynucléotides sont utilisés dans une variété de méthodes d'hybridation.

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