Fused pyrimidine derivatives with crf activity

Details Fused pyrimidine derivatives with crf activity Fused pyrimidine derivatives with crf activity

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2523261

This invention relates to compounds which are generally CRF-1 receptor antagonists and which are represented by Formula I wherein X1 is (CH2)~, n is 0 to 2 and R1, R2, R3 and R4 are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts thereof. The invention further relates to processes for preparing such compounds, to pharmaceutical compositions containing such compounds, and to methods for their use as therapeutic agents.

L'invention concerne des composés lesquels sont d'une manière générale des antagonistes du récepteur de CRF-1 et lesquels sont représentés par la formule I dans laquelle X?1¿ représente (CH¿2?)¿n?, n représente 0 à 2 et R?1¿, R?2¿, R?3¿ et R?4¿ ont la notation définie dans la description ; ou des isomères individuels, des mélanges racémiques ou non racémiques d'isomères ou leurs sels pharmaceutiquement acceptables. L'invention concerne également des procédés de préparation desdits composés, des compositions pharmaceutiques contenant ces composés ainsi que des méthodes pour leur utilisation comme agents thérapeutiques.

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