Molecular delivery vesicle

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/127 (2006.01) A61K 47/24 (2006.01)

Patent

CA 2697629

An isolated caveolin containing vesicle comprising a caveolin protein and at least one lipid, wherein at least about 30% of the at least one lipid is selected from phosphatidylethanolamine and phosphatidylglycerol is disclosed. Also disclosed is a method of making an isolated caveolin containing vesicle, an isolated caveolin containing vesicle comprising a recombinant caveolin protein, an isolated caveolin containing delivery vesicle, a method of making an isolated caveolin containing delivery vesicle and a method of treatment of a disease or condition by delivery of a molecule using the isolated caveolin containing delivery vesicle.

L'invention porte sur une vésicule contenant de la cavéoline isolée, constituée d'une protéine de type cavéoline et d'au moins un lipide, environ 30% au moins du lipide au nombre d'au moins un étant de la phosphatidyléthanolamine et/ou du phosphatidylglycérol. L'invention porte également sur un procédé de fabrication d'une vésicule contenant de la cavéoline isolée, sur une vésicule contenant de la cavéoline isolée dans laquelle cette dernière est une protéine recombinante, sur une vésicule d'administration contenant de la cavéoline isolée, sur un procédé de fabrication d'une vésicule d'administration contenant de la cavéoline isolée, et sur un procédé de traitement d'une maladie ou d'un état pathologique par administration d'une molécule à l'aide de la vésicule d'administration contenant de la cavéoline isolée.

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