Antibody detection of mismatch repair proteins

Details Antibody detection of mismatch repair proteins Antibody detection of mismatch repair proteins

G - Physics

01

N

G01N 33/574 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2223971

Antibodies directed to human protein mismatch repair proteins can be used diagnostically to discriminate between proliferating and non-proliferating cells. In addition, they can be used to determine whether cells have a mismatch repair defect caused by a mutation in e.g., hMSH2, hMLH1, or hPMS2. They can also be used to monitor the efficacy of anti-neoplastic therapies.

On peut utiliser à des fins diagnostiques des anticorps contre des protéines de réparation d'erreurs d'appariement de protéines humaines afin de distinguer des cellules proliférantes de cellules non proliférantes. De plus, on peut les utiliser pour déterminer si des cellules présentent un défaut de réparation d'erreurs d'appariement provoqué par une mutation dans, par exemple, hMSH2, hMLH1, ou hPMS2. On peut également les utiliser pour contrôler l'efficacité de thérapies anti-neoplasiques.

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