C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/675 (2006.01) A61K 31/70 (2006.01) A61K 51/00 (2006.01) C07D 471/04 (2006.01) C07F 9/6561 (2006.01) C07H 17/02 (2006.01)
Patent
CA 2280587
This invention is directed to compounds of the formula Image and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the specification, which are growth hormone secretogogues and which increase the level of endogenous growth hormone. The compounds of this invention are useful for the treatment and prevention of osteoporosis, congestive heart failure, frailty associated with aging, obesity; accelerating bone fracture repair, attenuating protein catabolic response after a major operation, reducing cachexia and protein loss due to chronic illness, accelerating wound healing, or accelerating the recovery of burn patients or patients having undergone major surgery; improving muscle strength, mobility, maintanence of skin thickness, metabolic homeostasis or renal homeostasis. The compounds of the present invention are also useful in treating osteoporosis when used in combination with: a bisphosphonate compound such as alendronate; estrogen, premarin, and optionally progesterone; a (33 adrenergic receptor agonist; an estrogen agonist or antagonist; or calcitonin, and pharmaceutical compositions useful therefor. Further, the present invention is directed to pharmaceutical compositions useful for increasing the endogenous production or release of growth hormone in a human or other animal which comprises an effective amount of a compound of the present invention and a growth hormone secretagogue selected from GHRP-6, Hexarelin, GHRP-1, growth hormone releasing factor (GRF), IGF-1, IGF-2 or B-HT920.
Pfizer Products Inc.
Smart & Biggar
LandOfFree
Growth hormone secretagogues does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Growth hormone secretagogues, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Growth hormone secretagogues will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1858156