Generating an immune response by inducing cd40 and pattern...

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) A61K 35/12 (2006.01) A61K 49/00 (2006.01) A61P 37/04 (2006.01) C12N 15/00 (2006.01) A61K 48/00 (2006.01) C12N 5/00 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2666667

Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing pattern recognition receptor activity, and CD40 activity. Also provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing CD40 activity without prostaglandin E2. Also provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible chimeric molecule comprising a region of a pattern recognition receptor or an adaptor thereof.

L'invention concerne des procédés pour activer une cellule présentant des antigènes et provoquer une réponse immune en induisant une activité d'un récepteur de reconnaissance de structures et une activité CD40. L'invention concerne aussi des procédés pour activer une cellule présentant des antigènes et provoquer une réponse immune en induisant une activité CD40 sans prostaglandine E2. L'invention concerne encore des procédés pour activer une cellule présentant des antigènes et provoquer une réponse immune en induisant une molécule chimérique inductible comprenant une zone d'un récepteur de reconnaissance de structures ou un adaptateur de celui-ci.

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