A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/555 (2006.01) C07F 15/02 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2248964
Pharmaceutical compositions of low molecular weight mimics of superoxide dismutase (SOD) represented by formula (I), wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, and R'9, and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, inflammatory bowel disease and all other conditions of oxidant-induced tissue damage or injury.
Des compositions pharmaceutiques renfermant des imitateurs de faible masse moléculaire de superoxyde-dismutase (SOD) représentés par la formule (I), dans laquelle R, R', R¿1?, R'¿1?, R¿2?, R'¿2?, R¿3?, R'¿3?, R¿4?, R'¿4?, R¿5?, R'¿5?, R¿6?, R'¿6?, R¿7?, R'¿7?, R¿8?, R'¿8?, R¿9?, et R'¿9? ainsi que X, Y, Z et n ont la notation ci-définie, sont utiles en tant qu'agents thérapeutiques contre des états et des troubles pathologiques inflammatoires, des lésions ischémiques/de reperfusion, les attaques, l'athérosclérose, les infections intestinales inflammatoires et tout autre état de détérioration ou de lésion tissulaire induite par un oxydant.
Riley Dennis P.
Monsanto Company
Osler Hoskin & Harcourt Llp
LandOfFree
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